Author

Harry S. Nick

University of FloridaORCID 0000-0002-0374-2283Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:imaging· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Jennifer White· 2 shared Jerelyn A. NickiD· 2 shared Junxiang YiniD· 2 shared Kyle D. AlleniD· 2 shared Michael F. WatersiD· 2 shared Michael WuiD· 2 shared Swati Khare· 2 shared Aamir R. ZuberiiD· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersNeuroscience

Jennifer White

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Association of cerebellar inflammation and neurodegeneration in a novel spinocerebellar ataxia type 13 mouse model

Junxiang Yin, Jennifer White, Swati Khare, Michael Wu, Aamir R. Zuberi, Ming Gao, Jerelyn A. Nick, Cathleen M. Lutz, Kyle D. Allen, Harry S. Nick, Michael F. Waters

This study creates a novel SCA13 mouse model with a R424H mutation, showing motor deficits, Purkinje cell loss, cerebellar inflammation, and atrophy, linking neuroinflammation to neurodegeneration.

bioRxiv · Oct 28, 2024 · PreprintNeuroscience

A Novel Early Onset Spinocerebellar Ataxia 13 BAC Mouse Model with Cerebellar Hypoplasia, Tremor, and Ataxic Gait

Junxiang Yin, Jerelyn A. Nick, Swati Khare, Heidi E. Kloefkorn, Ming Gao, Michael Wu, Jennifer White, James L. Resnick, Kyle D. Allen, Harry S. Nick, Michael F. Waters

This paper presents a novel BAC mouse model of SCA13 with cerebellar hypoplasia, tremor, and ataxic gait, mimicking human disease features.

bioRxiv · Oct 28, 2024 · PreprintNeuroscience

geneBasis: an iterative approach for unsupervised selection of targeted gene panels from scRNA-seq.

Alsu M. Missarova, Jaison Jain, Andrew Butler, Shila Ghazanfar, Tim Stuart, Maigan Brusko, Clive Henry Wasserfall, Harry S. Nick, Todd M. Brusko, Mark A. Atkinson, Rahul Satija, John C. Marioni

geneBasis selects an optimal gene panel from scRNA-seq data by iteratively adding genes that maximize manifold distance, outperforming existing methods in resolving cell types and states.

Genome biology · Dec 1, 2021Peer-reviewedBioinformatics