Functional inactivation of the telomerase chaperone TCAB1 primes cells for the activation of ALT in osteosarcoma
Joshua Keegan, Sydney Sorbello, Joakin Mori, Shugo Muratani, Ignaty Leshchiner, Christopher M. Heaphy, Rachel Litman Flynn
The paper identifies structural variations in TP53 that inactivate TCAB1, a telomerase chaperone, and show these variations are prevalent in ALT-positive osteosarcoma tumors.
bioRxiv · Jan 2, 2026 · PreprintCancer Biology