Author

Rachel Litman Flynn

Boston UniversityORCID 0000-0003-0562-1909Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ignaty LeshchineriD· 2 shared Andrés A. Quiñones-MolinaiD· 1 shared Andrew A. LealiD· 1 shared Andrew J. HendersoniD· 1 shared Christopher M. HeaphyiD· 1 shared Daniel L. Bryant· 1 shared Joakin MoriiD· 1 shared Joseph B McWhirteriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Ignaty LeshchinerORCID

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2 papers

Recent·Most cited

MicrobiologybioRxivPreprintApr 27, 2026

Bloom syndrome helicase is required for efficient HIV-1 reverse transcription in macrophages

Andrew A. Leal, Samantha Tafrate, Xianbao He…·Andrew J. Henderson

This study identifies Bloom syndrome helicase (BLM) as a host factor that promotes HIV-1 reverse transcription and integration in macrophages through CRISPR screening and functional assays.

DOI 10.64898/2026.04.26.720894

humangenetic perturbation / CRISPR

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJan 2, 2026

Functional inactivation of the telomerase chaperone TCAB1 primes cells for the activation of ALT in osteosarcoma

Joshua Keegan, Sydney Sorbello, Joakin Mori…·Rachel Litman Flynn

The paper identifies structural variations in TP53 that inactivate TCAB1, a telomerase chaperone, and show these variations are prevalent in ALT-positive osteosarcoma tumors.

DOI 10.64898/2026.01.02.691864

humanwhole-genome sequencing

𝕏 PostBluesky