Author

Sylvia Lai

Osaka Metropolitan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pathology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:imaging· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Daisuke TsurutaiD· 4 shared Ichiro KatayamaiD· 4 shared Lingli YangiD· 3 shared Yasutaka KurodaiD· 3 shared Fei YangiD· 2 shared Takuo Yuki· 2 shared Tetsuya Sayo· 2 shared Yoshito TakahashiiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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4 shared papersCell Biology

Daisuke TsurutaORCID

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4 papers

Recent·Most cited

Staurosporine drives non-canonical melanocyte maturation by coupling β-catenin signaling to actin-dependent dendrite remodeling

Kangning Xu, Lingli Yang, Sylvia Lai, Fei Yang, Yasutaka Kuroda, Daisuke Tsuruta, Ichiro Katayama

This paper shows that staurosporine induces non-canonical melanocyte maturation by enhancing melanogenesis and dendritic remodeling, promoting pigmentation in vitro and in vivo.

Pigment Cell & Melanoma Research · Aug 13, 2026Peer-reviewedCell Biology

Circadian clock regulates epidermal endocrine system in homeostatic skin pigmentation

Anya Zhu, Lingli Yang, Sylvia Lai, Fei Yang, Daisuke Tsuruta, Ichiro Katayama

This study shows that circadian clock genes BMAL1 and CLOCK regulate melanin synthesis in melanocytes by modulating vitamin D signaling.

Experimental Dermatology · Jun 1, 2026Peer-reviewedPathology

Aberrant laminin signaling drives melanocyte dedifferentiation and unveils a tractable therapeutic target in vitiligo

Fei Yang, Lingli Yang, Sylvia Lai, Masafumi Yokota, Yasutaka Kuroda, Takuo Yuki, Yoshito Takahashi, Tetsuya Sayo, Takeshi Namiki, Hiroyuki Goto, Sho Hiroyasu, Shigetoshi Sano, SHINTARO INOUE, Yoichi Mizukami, Daisuke Tsuruta, Ichiro Katayama

This study identifies melanocyte dedifferentiation as a reversible mechanism in vitiligo and shows that targeting specific pathways can restore pigmentation.

Nature Communications · Apr 17, 2026Peer-reviewedCell Biology

The fate of melanocytes and the disorganization of basement membrane in a guinea pig model of Rhododendrol-induced chemical vitiligo

Yasutaka Kuroda, Fei Yang, Lingli Yang, Sylvia Lai, Takuo Yuki, Tetsuya Sayo, Yoshito Takahashi, Daisuke Tsuruta, Ichiro Katayama

This study investigates RD-induced melanocyte loss in guinea pigs, finding basement membrane disorganization and MMP2 activity contribute to melanocyte detachment and depigmentation.

bioRxiv · Sep 24, 2025 · PreprintPathology