Author
Sylvie Dirrig‐Grosch
Inserm
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2021-2024 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 42 mutual co-author links4 papers
Recent·Most cited
- NeuroscienceMolecular NeurodegenerationPeer-reviewed
Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.
Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis‐Downes…·Luc Dupuis
This study shows that wild-type FUS rescues ALS-like disease caused by mutant FUS by activating an autoregulatory loop that reduces cytoplasmic mutant FUS levels.
21 citations - Genetic & Genomic MedicinemedRxivPreprint
Loss of nucleoporin Nup50 is a risk factor for amyotrophic lateral sclerosis
Salim Megat, Natalia Mora, Jason Sanogo…·Luc Dupuis
The paper identifies NUP50 gene variants and reduced expression as risk factors for ALS through transcriptome-wide association and functional studies.
6 citations - NeuroscienceNature CommunicationsPeer-reviewed
Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses
Jelena Scekic‐Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa W. Y. Kan…·Luc Dupuis
This study shows that cytoplasmic FUS mislocalization in mice causes behavioral changes and inhibitory synaptic defects without widespread neuronal loss.
66 citationstop 4%