Author

Gina Picchiarelli

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Neuroscience· 4

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Organism:mouse· 4 Approach:experimental assay· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Luc DupuisiD· 4 shared Stéphane DieterleiD· 4 shared Clotilde Lagier‐TourenneiD· 3 shared Salim MegatiD· 3 shared Albert Christian LudolphiD· 2 shared Anne‐Laurence BoutillieriD· 2 shared Inmaculada Sanjuan-RuiziD· 2 shared Laura TzeplaeffiD· 2 shared

Activity by Year

2021-2024 · peak 3/yr

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10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Luc DupuisORCID

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4 papers

Recent·Most cited

FUS controls muscle differentiation and structure through LLPS mediated recruitment of MEF2 and ETV5

Gina Picchiarelli, Anne Wienand, Salim Megat, Amr Aly, Marije Been, Nibha Mishra, Saskia Hutten, Erin L. Sternburg, Pierre Cauchy, Stéphane Dieterle, Marica Catinozzi, Valérie Demais, Laura Tzeplaeff, Annemarie Huebers, Dagmar Zeuschner, , Luc Dupuis

This study identifies FUS's role in muscle differentiation and structure through phase separation-mediated recruitment of ETV5 and MEF2, showing its dysfunction in FUS-ALS.

bioRxiv · Sep 18, 2024 · PreprintNeuroscience

Wild-type FUS corrects ALS-like disease induced by cytoplasmic mutant FUS through autoregulation.

Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis‐Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig‐Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W. Cleveland, Clotilde Lagier‐Tourenne, Sandrine Da Cruz, Luc Dupuis

This study shows that wild-type FUS rescues ALS-like disease caused by mutant FUS by activating an autoregulatory loop that reduces cytoplasmic mutant FUS levels.

Molecular Neurodegeneration · Sep 6, 2021Peer-reviewedNeuroscience

Cytoplasmic accumulation of FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and defects in inhibitory synapses

Jelena Scekic‐Zahirovic, Inmaculada Sanjuan-Ruiz, Vanessa W. Y. Kan, Salim Megat, Pierre De Rossi, Stéphane Dieterle, Raphaelle Cassel, Marguerite Jamet, Pascal Kessler, Diana Wiesner, Laura Tzeplaeff, Valérie Demais, Sonu Sahadevan, Katharina Hembach, Hans‐Peter Müller, , Luc Dupuis

This study shows that cytoplasmic FUS mislocalization in mice causes behavioral changes and inhibitory synaptic defects without widespread neuronal loss.

Nature Communications · May 21, 2021Peer-reviewedNeuroscience

Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression

Júlia Canet-Pons, Nesli-Ece Şen, Aleksandar Arsović, Luis Enrique Almaguer-Mederos, Melanie Vanessa Halbach, Jana Key, Claudia Döring, Anja Kerksiek, Gina Picchiarelli, Raphaelle Cassel, Frédérique René, Stéphane Dieterle, Nina V. Fuchs, Renate König, Luc Dupuis, , Georg W. J. Auburger

This study examines an SCA2 mouse model to identify molecular mechanisms of spinal cord pathology, finding progressive TDP43 aggregation and cholesterol biosynthesis suppression.

Neurobiology of Disease · Feb 10, 2021Peer-reviewedNeuroscience