Exploring the mechanisms of early acquired resistance to doxorubicin in melanoma spheroids
Giorgiana Negrea, Ilie Ovidiu Pavel, Loredana Bălăcescu, Bogdan-Razvan Dume, Emilia Licărete, Valentin Florian Rauca, Laura Pătraș, Szilvia Meszaros, Stefan Dragan, Vlad Alexandru Toma, Manuela Banciu, Alina Sesărman
This study examines how melanoma spheroids develop early resistance to doxorubicin through adaptive molecular changes, including upregulated angiogenesis and cell migration.
bioRxiv · Apr 7, 2025 · PreprintCancer Biology