Myeloid DC-SIGN drives tumor immune evasion and resistance to PD-1 blockade through ICAM-2-ERM-mediated T-cell mechanosuppression
Ting Pan, T Z Wang, Jiaqi Wu, Heping Wang, Bo Zeng, Yangyang Li, Ming Yi, Ruirui He, Lingyun Feng, Zhihui Cui, Guoling Huang, Panyin Shu, Xi Li, Yuan Wang, Yanyun Du, , Ce Wang
This study identifies DC-SIGN as a mechanosuppressive checkpoint that drives tumor immune evasion and resistance to PD-1 blockade by suppressing T-cell function through ICAM-2-ERM signaling.
bioRxiv · Jun 16, 2026 · PreprintImmunology