ImmunologybioRxivPreprint
Myeloid DC-SIGN drives tumor immune evasion and resistance to PD-1 blockade through ICAM-2-ERM-mediated T-cell mechanosuppression
Ting Pan, T Z Wang, Jiaqi Wu…·Ce Wang
This study identifies DC-SIGN as a mechanosuppressive checkpoint that drives tumor immune evasion and resistance to PD-1 blockade by suppressing T-cell function through ICAM-2-ERM signaling.