Targeting AKT elicits tumor suppressive functions of FOXO transcription factors and GSK3 kinase in Multiple Myeloma
T. A. Bloedjes, G. de Wilde, C. Maas, E. E. Eldering, R. J. Bende, C. J. van Noesel, S. T. Pals, M. Spaargaren, J. E. Guikema
This study shows that AKT inhibition in multiple myeloma activates FOXO and GSK3, leading to MCL1 reduction and cell death, suggesting potential for combination therapies.
bioRxiv · Oct 24, 2019Cancer Biology