Author

T. A. Kadlecek

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Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

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A. Weiss· 1 shared J. K. Chung· 1 shared J. Kuriyan· 1 shared J. T. Groves· 1 shared L. M. Nocka· 1 shared Q. Wang· 1 shared

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2018-2018 · peak 1/yr

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1 shared paperBiophysics

A. Weiss

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1 paper

Recent·Most cited

Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization

J. K. Chung, L. M. Nocka, Q. Wang, T. A. Kadlecek, A. Weiss, J. Kuriyan, J. T. Groves

The paper identifies a switch-like PIP3 sensing mechanism in Btk's PH-TH module that enhances sensitivity through dimerization and multiple PIP3 binding.

bioRxiv · Mar 17, 2018Biophysics