Author

J. K. Chung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 1

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Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 3 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. T. Groves· 4 shared L. M. Nocka· 2 shared A. N. Parikh· 1 shared A. Weiss· 1 shared B. D. Engel· 1 shared C. B. Carbone· 1 shared C. Jacobs-Wagner· 1 shared C. Mattos· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersBiophysics

J. T. Groves

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Author profile →

4 papers

Recent·Most cited

Raf promotes dimerization of the Ras G-domain with increased allosteric connections

M. Packer, J. A. Parker, J. K. Chung, Z. Li, Y. K. Lee, T. Cookis, H. Guterres, S. Alvarez, M. A. Hossain, D. P. Donnelly, J. N. Agar, L. Makowski, M. Buck, J. T. Groves, C. Mattos

This study shows Raf-RBD induces Ras dimerization and identifies allosteric connections between Raf-RBD residues that contribute to signaling complex formation.

Proceedings of the National Academy of Sciences · Mar 9, 2021Peer-reviewedBiophysics

Coupling between lipid miscibility and phosphotyrosine driven protein condensation at the membrane

J. K. Chung, W. Y. C. Huang, C. B. Carbone, L. M. Nocka, A. N. Parikh, R. Vale, J. T. Groves

The paper shows that LAT protein condensation on membrane surfaces drives lipid phase separation, which in turn localizes K-Ras into the condensate, controlled by tyrosine phosphorylation.

bioRxiv · Jul 22, 2020 · PreprintBiophysics

Switch-like activation of Bruton’s tyrosine kinase by membrane-mediated dimerization

J. K. Chung, L. M. Nocka, Q. Wang, T. A. Kadlecek, A. Weiss, J. Kuriyan, J. T. Groves

The paper identifies a switch-like PIP3 sensing mechanism in Btk's PH-TH module that enhances sensitivity through dimerization and multiple PIP3 binding.

bioRxiv · Mar 17, 2018Biophysics

mTORC1 controls phase-separation and the biophysical properties of the cytoplasm by tuning crowding

M. Delarue, G. P. Brittingham, S. Pfeffer, I. Surovtsev, K. J. Kennedy, S. Pinglay, J. I. Gutierrez, M. Schaffer, J. K. Chung, J. Plitzko, J. T. Groves, C. Jacobs-Wagner, B. D. Engel, L. J. Holt

The paper investigates how mTORC1 regulates macromolecular crowding and biophysical properties of the cytoplasm by using GEMs to measure diffusion and phase-separation changes.

bioRxiv · Dec 29, 2017Cell Biology