BRAF inhibitors reprogram cancer-associated fibroblasts to drive matrix remodeling and therapeutic escape in melanoma
T. Liu, L. Zhou, Y. Xiao, T. Andl, Y. Zhang
This study shows BRAF inhibitors reprogram cancer-associated fibroblasts to promote matrix remodeling and resistance to therapy in melanoma by enhancing β-catenin signaling and POSTN expression.
bioRxiv · Feb 18, 2021Cancer Biology