Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture
K. Bafna, K. White, B. Harish, R. Rosales, T. A. Ramelot, T. B. Acton, E. Moreno, T. Kehrer, C. A. Royer, A. Garcia-Sastre, R. M. Krug, G. T. Montelione
This paper evaluates HCV protease inhibitors as potential SARS-CoV-2 antivirals, finding that simeprevir and grazoprevir synergize with remdesivir to enhance antiviral activity against SARS-CoV-2 in cell culture.
bioRxiv · Dec 13, 2020Biochemistry