Author

C. A. Royer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:yeast· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1

Frequent Co-Authors

M. Tyers· 3 shared S. Tollis· 3 shared G. Ghazal· 2 shared G. T. Montelione· 2 shared J. Cheng· 2 shared J. Coulombe-Huntington· 2 shared Y. Thattikota· 2 shared A. C. Bourges· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

M. Tyers

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Swi4-dependent SWI4 transcription couples cell size to cell cycle commitment

P. Goswami, A. Ghimire, C. Coffin, J. Cheng, J. Coulombe-Huntington, G. Ghazal, Y. Thattikota, M. Tyers, S. Tollis, C. A. Royer

This study shows that Swi4-dependent transcription couples cell size to cell cycle commitment in budding yeast by regulating Swi4 accumulation and Start timing.

bioRxiv · Nov 29, 2023Cell Biology

Structural Evolution of the Ancient Enzyme, Dissimilatory Sulfite Reductase

D. R. Colman, G. Labesse, G. V. T. Swapna, J. Stefanakis, G. T. Montelione, E. S. Boyd, C. A. Royer

The paper investigates structural evolution of DsrAB across sulfate-reducing organisms, identifying conserved features and allostery-related co-variance patterns.

bioRxiv · Dec 28, 2021Biophysics

Hepatitis C Virus Drugs Simeprevir and Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV-2 Replication in Cell Culture

K. Bafna, K. White, B. Harish, R. Rosales, T. A. Ramelot, T. B. Acton, E. Moreno, T. Kehrer, C. A. Royer, A. Garcia-Sastre, R. M. Krug, G. T. Montelione

This paper evaluates HCV protease inhibitors as potential SARS-CoV-2 antivirals, finding that simeprevir and grazoprevir synergize with remdesivir to enhance antiviral activity against SARS-CoV-2 in cell culture.

bioRxiv · Dec 13, 2020Biochemistry

A nitrogen source-regulated microprotein confers an alternative mechanism of G1/S transcriptional activation in budding yeast

S. Tollis, J. Singh, Y. Thattikota, R. Palou, G. Ghazal, J. Coulombe-Huntington, X. Tang, S. Moore, D. Blake, E. Bonneil, C. A. Royer, P. Thibault, M. Tyers

The paper identifies NRS1, a nitrogen-responsive microprotein in budding yeast, that provides an alternative mechanism for G1/S transcriptional activation under poor nitrogen conditions.

bioRxiv · Apr 20, 2020 · PreprintCell Biology

G1/S transcription factors assemble in discrete clusters that increase in number as cells grow

L. Black, S. Tollis, G. Fu, J.-B. Fiche, S. Dorsey, J. Cheng, S. Notley, B. Crevier, J. Bigness, M. Nollmann, M. Tyers, C. A. Royer

The paper uses PALM to show SBF/MBF transcription factors form clusters in yeast cells, with cluster number increasing as cells grow.

bioRxiv · Nov 28, 2019Cell Biology

Quantitative high-resolution imaging of live microbial cells at high hydrostatic pressure

A. C. Bourges, A. Lazarev, N. Declerck, K. L. Rogers, C. A. Royer

This paper uses high-pressure imaging to study microbial responses to extreme pressure, revealing pressure-dependent metabolic and protein interaction changes in live cells.

bioRxiv · Nov 20, 2019Microbiology