Author

T. B. Friedman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. R. Sellers· 3 shared Y. Takagi· 3 shared A. Shams· 2 shared E. Wilson· 2 shared F. Jiang· 2 shared J. E. Bird· 2 shared A. Nagy· 1 shared A. Parker· 1 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

J. R. Sellers

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Author profile →

4 papers

Recent·Most cited

Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing

Z. G. Moreland, F. Jiang, C. Aguilar, M. Barzik, R. Gong, A. Shams, C. Faaborg-Andersen, J. C. Werth, R. Harley, D. C. Sutton, S. M. Cole, A. Parker, S. Morse, E. Wilson, Y. Takagi, , J. E. Bird

This study identifies a mutation in MYO15 that disrupts actin nucleation at stereocilia tips, causing hearing loss by impairing stereocilia growth.

bioRxiv · Jul 9, 2021 · PreprintCell Biology

TRIOBP promotes bidirectional radial stiffness gradients within the organ of Corti

H. Babahosseini, I. Belyantseva, R. Yousaf, R. Tona, S. Hadi, E. Wilson, S.-i. Kitajiri, G. Frolenkov, T. B. Friedman, A. X. Cartagena-Rivera

The paper uses PFT-AFM to map stiffness gradients in cochlear epithelium, showing TRIOBP deficiency alters radial stiffness gradients and affects hearing.

bioRxiv · Jun 28, 2021 · PreprintBiophysics

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 deafness

F. Jiang, Y. Takagi, A. Shams, S. M. Heissler, T. B. Friedman, J. R. Sellers, J. E. Bird

This study characterizes the ATPase mechanism of MYO15A, a motor protein involved in stereocilia development, and identifies its kinetic properties relevant to hearing loss.

bioRxiv · Jun 17, 2020Biochemistry

Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties

L. Melli, N. Billington, S. A. Sun, J. Bird, A. Nagy, T. B. Friedman, Y. Takagi, J. R. Sellers

This study compares the motile and mechanical properties of NM-2A and NM-2B filaments, showing that NM2-A filaments require specific conditions to move processively.

bioRxiv · Nov 2, 2017Biophysics