Author

J. E. Bird

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cell Biology· 2 Biophysics· 1 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Approach:microscopy & imaging analysis· 2 Organism:mouse· 2

Frequent Co-Authors

A. Shams· 3 shared F. Jiang· 3 shared G. M. Alushin· 2 shared J. R. Sellers· 2 shared M. R. Bowl· 2 shared R. Gong· 2 shared T. B. Friedman· 2 shared Y. Takagi· 2 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

A. Shams

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

An Optimized Approach to Study Sub-Sarcomere Structure Utilizing Super-Resolution Microscopy with Secondary VHH Nanobodies

C. M. Douglas, J. E. Bird, D. Kopinke, K. A. Esser

This study develops a method to visualize sub-sarcomere structures using optimized super-resolution microscopy and VHH nanobodies, enabling precise protein localization analysis in skeletal muscle.

bioRxiv · Sep 7, 2022 · PreprintPhysiology

Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing

Z. G. Moreland, F. Jiang, C. Aguilar, M. Barzik, R. Gong, A. Shams, C. Faaborg-Andersen, J. C. Werth, R. Harley, D. C. Sutton, S. M. Cole, A. Parker, S. Morse, E. Wilson, Y. Takagi, , J. E. Bird

This study identifies a mutation in MYO15 that disrupts actin nucleation at stereocilia tips, causing hearing loss by impairing stereocilia growth.

bioRxiv · Jul 9, 2021 · PreprintCell Biology

Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia

R. Gong, F. Jiang, Z. G. Moreland, M. J. Reynolds, S. Espinosa de los Reyes, P. S. Gurel, A. Shams, M. R. Bowl, J. E. Bird, G. M. Alushin

This paper presents cryo-EM structures of myosin-15 bound to F-actin, revealing how mutations affect actin polymerization and stereocilia elongation.

bioRxiv · Jul 9, 2021Biophysics

DNMT3A harboring leukemia-associated mutations directs sensitivity to DNA damage at replication forks

K. Venugopal, P. Nowialis, Y. Feng, D. E. Shabashvili, C. M. Berntsen, K. I. Krajcik, C. Taragjini, Z. Zaroogian, H. L. Casellas-Roman, L. M. Posada, C. Gunaratne, J. Li, D. Dupere-Richer, R. L. Bennett, S. Pondugula, , O. A. Guryanova

This study shows that DNMT3A mutations impair replication fork recovery, leading to DNA damage and sensitivity to nucleoside analogs like cytarabine.

bioRxiv · May 28, 2021Cancer Biology

Pore dynamics and asymmetric cargo loading in an encapsulin nanocompartment

J. Ross, Z. McIver, T. Lambert, C. Piergentili, K. J. Gallagher, J. E. Bird, F. L. Cruickshank, P. James, E. Zarazua-Arvizu, L. E. Horsfall, K. J. Waldron, M. D. Wilson, C. L. Mackay, A. Basle, D. J. Clarke, J. Marles-Wright

The paper uses cryo-EM and HDX-MS to analyze an encapsulin nanocompartment, revealing asymmetric cargo loading and dynamic pore behavior.

bioRxiv · Apr 15, 2021Biochemistry

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 deafness

F. Jiang, Y. Takagi, A. Shams, S. M. Heissler, T. B. Friedman, J. R. Sellers, J. E. Bird

This study characterizes the ATPase mechanism of MYO15A, a motor protein involved in stereocilia development, and identifies its kinetic properties relevant to hearing loss.

bioRxiv · Jun 17, 2020Biochemistry

Mechanotransduction-dependent control of stereocilia dimensions and row identity in inner hair cells

J. F. Krey, P. Chatterjee, R. A. Dumont, D. Choi, J. E. Bird, P. G. Barr-Gillespie

This study shows that mechanotransduction channels specify and maintain stereocilia row identity and control their diameter in inner hair cells.

bioRxiv · Aug 13, 2019Cell Biology