Hematopoietic progenitors polarize in contact with bone marrow stromal cells by engaging CXCR4 receptors.
T. Bessy, B. Souquet, B. Vianay, A. Schaeffer, T. Jaffredo, J. Larghero, L. Blanchoin, S. Brunet, L. Faivre, M. Thery
This study shows that hematopoietic progenitors polarize when in contact with bone marrow stromal cells via CXCR4 receptors, leading to cytoskeletal reorganization and centrosome-microtubule network polarization.
bioRxiv · May 11, 2020Cell Biology