J. Larghero

heterotypic interaction promotes asymmetric division of human hematopoietic stem and progenitor cells

This study shows that interaction with osteoblasts promotes asymmetric division of human HSPCs, leading to unequal inheritance of lysosomes and differentiation markers.

Self-organization of Long-lasting Human Endothelial Capillary Networks guided by DLP Bioprinting

This paper uses DLP bioprinting to guide endothelial cells into self-organizing vascular networks, demonstrating stable capillary-like structures with various geometries.

Distinct Subsets of Multi-Lymphoid Progenitors Support Ontogeny-Related Changes in Human Lymphopoiesis

This study identifies three waves of multi-lymphoid progenitors in human lymphopoiesis, showing ontogeny-related shifts in lineage bias and CD127+ ELP production.

Construction of functional biliary epithelial branched networks with predefined geometry using digital light stereolithography

This study uses digital light stereolithography to create 3D hydrogel structures that guide cholangiocytes into branched tubular networks with epithelial features.

Self-organization and culture of Mesenchymal Stromal Cell spheroids in acoustic levitation

This study develops a scaffold-free 3D cell culture method using acoustic levitation to generate MSC spheroids, showing improved viability and differentiation capacity compared to 2D cultures.

Hematopoietic progenitors polarize in contact with bone marrow stromal cells by engaging CXCR4 receptors.

This study shows that hematopoietic progenitors polarize when in contact with bone marrow stromal cells via CXCR4 receptors, leading to cytoskeletal reorganization and centrosome-microtubule network polarization.

Microtubules deform the nucleus and force chromatin reorganization during early differentiation of human hematopoietic stem cells.

The paper shows microtubules cause nuclear invaginations and chromatin reorganization in human HSCs during myeloid differentiation, linking nuclear shape to gene expression changes.