B. Vianay

Deletion of FAT1 in hybrid EMT cells stimulates the migration of neighboring non-mutant cells through secretion of extracellular vesicles

heterotypic interaction promotes asymmetric division of human hematopoietic stem and progenitor cells

This study shows that interaction with osteoblasts promotes asymmetric division of human HSPCs, leading to unequal inheritance of lysosomes and differentiation markers.

Microtubules under mechanical pressure can breach dense actin networks

The paper shows microtubules can breach dense actin networks under mechanical pressure when immobilized.

Recycling limits the lifetime of actin turnover

This study investigates how actin turnover is sustained with a limited monomer pool by analyzing bead motility and identifying recycling as a key factor.

Microtubules self-repair in living cells

This study demonstrates that microtubules self-repair in living cells by incorporating injected tubulin dimers, showing spatial and temporal dynamics in PtK2 cells.

The architecture of the actin network can balance the pushing forces produced by growing microtubules.

This study shows that actin network architecture modulates MTOC positioning by balancing pushing forces from growing microtubules.

Microtubules tune mechanosensitive cell responses

This study shows that microtubule acetylation, regulated by actomyosin mechanosensing, influences RhoA activation and cell migration.

Hematopoietic progenitors polarize in contact with bone marrow stromal cells by engaging CXCR4 receptors.

This study shows that hematopoietic progenitors polarize when in contact with bone marrow stromal cells via CXCR4 receptors, leading to cytoskeletal reorganization and centrosome-microtubule network polarization.

Acto-myosin network geometry defines centrosome position

This study shows that centrosome positioning is determined by actin network geometry rather than cell shape, with dynein forces placing the centrosome in an inner zone defined by actin contraction.

Microtubules deform the nucleus and force chromatin reorganization during early differentiation of human hematopoietic stem cells.

The paper shows microtubules cause nuclear invaginations and chromatin reorganization in human HSCs during myeloid differentiation, linking nuclear shape to gene expression changes.

Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts

Variation in traction forces during cell cycle progression

The paper measures traction forces during the cell cycle and finds they increase in G1, plateau in S phase, and decrease in G2, revealing a previously unknown regulation of cell contractility.