Author

T. Brock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

D. A. Starr· 2 shared G. G. Luxton· 2 shared C. E. Hopkins· 1 shared C. Hopkins· 1 shared E. F. Gregory· 1 shared G. Bonne· 1 shared L. Resch· 1 shared Q. K.-G. Tan· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

D. A. Starr

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2 papers

Recent·Most cited

Caenorhabditis elegans models for striated muscle disorders caused by missense variants of human LMNA

E. F. Gregory, S. Kalra, T. Brock, G. Bonne, G. G. Luxton, C. Hopkins, D. A. Starr

This paper creates C. elegans models for striated muscle laminopathies by introducing human LMNA variants, finding that variants affecting both skeletal and cardiac muscle cause more severe phenotypes.

bioRxiv · Apr 9, 2023 · PreprintCell Biology

A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4

S. Gumusderelioglu, L. Resch, T. Brock, Undiagnosed Diseases Network, G. G. Luxton, Q. K.-G. Tan, C. E. Hopkins, D. A. Starr

The paper identifies a KLC4 variant linked to Hereditary Spastic Paraplegia and tests its effects in a humanized C. elegans model, showing early lethality and nuclear migration defects in homozygous variants.

bioRxiv · Jan 7, 2023 · PreprintCell Biology