Author

G. G. Luxton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 4 Research Focus:cell type annotation· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:C. elegans· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Organism:human· 2

Frequent Co-Authors

D. A. Starr· 2 shared T. Brock· 2 shared A. C. Rowat· 1 shared A. J. Booth· 1 shared A. Vahabikashi· 1 shared C. A. Saunders· 1 shared C. E. Hopkins· 1 shared C. Hopkins· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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2 shared papersCell Biology

D. A. Starr

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Author profile →

6 papers

Recent·Most cited

Caenorhabditis elegans models for striated muscle disorders caused by missense variants of human LMNA

E. F. Gregory, S. Kalra, T. Brock, G. Bonne, G. G. Luxton, C. Hopkins, D. A. Starr

This paper creates C. elegans models for striated muscle laminopathies by introducing human LMNA variants, finding that variants affecting both skeletal and cardiac muscle cause more severe phenotypes.

bioRxiv · Apr 9, 2023 · PreprintCell Biology

A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia-associated variants in kinesin light chain KLC4

S. Gumusderelioglu, L. Resch, T. Brock, Undiagnosed Diseases Network, G. G. Luxton, Q. K.-G. Tan, C. E. Hopkins, D. A. Starr

The paper identifies a KLC4 variant linked to Hereditary Spastic Paraplegia and tests its effects in a humanized C. elegans model, showing early lethality and nuclear migration defects in homozygous variants.

bioRxiv · Jan 7, 2023 · PreprintCell Biology

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole cell mechanics

A. Vahabikashi, S. Sivagurunathan, F. A. S. Nicdao, Y. L. Han, C. Y. Park, X. Wong, J. R. Tran, G. G. Gundersen, K. Reddy, G. G. Luxton, M. Guo, J. J. Fredberg, Y. Zheng, S. A. Adam, R. D. Goldman

This study shows that different nuclear lamin isoforms modulate cell and nuclear mechanics by affecting LINC complex stability and heterochromatin structure in mouse embryonic fibroblasts.

bioRxiv · May 12, 2021Biophysics

Identifying hetero-protein complexes in the nuclear envelope

J. Hennen, K.-H. Hur, J. Kohler, S. R. Karuka, I. Angert, G. G. Luxton, J. Mueller

This paper introduces dual-color tsMSQ to identify hetero-protein complexes in the nuclear envelope and demonstrates its application to the LINC complex.

bioRxiv · Jul 19, 2019Biophysics

Contractile acto-myosin network on nuclear envelope remnants positions human chromosomes for mitosis

A. J. Booth, Z. Yue, J. K. Eykelenboom, T. Stiff, G. G. Luxton, H. Hochegger, T. U. Tanaka

The paper quantifies chromosome-scattering volume and shows that an acto-myosin network on nuclear envelope remnants reduces it, facilitating chromosome capture by spindle microtubules during mitosis.

bioRxiv · Mar 15, 2019Cell Biology

DYT1 dystonia patient-derived fibroblasts have increased deformability and susceptibility to damage by mechanical forces.

N. K. Gill, C. Ly, P. H. Kim, C. A. Saunders, L. G. Fong, S. G. Young, G. G. Luxton, A. C. Rowat

This study examines the mechanotype of fibroblasts from DYT1 dystonia patients and mice lacking torsinA, finding increased deformability and susceptibility to mechanical damage.

bioRxiv · Nov 28, 2018Biophysics