Mechanisms underpinning osteosarcoma genome complexity and evolution
J. Espejo Valle-Inclan, S. De Noon, K. Trevers, H. Elrick, M. Tanguy, T. Butters, F. Muyas, F. Amary, R. Tirabosco, A. Giess, A. Sosinky, G. Elgar, A. M. Flanagan, I. Cortes-Ciriano
This study identifies chromothripsis and a novel LTA chromothripsis mechanism driving genome complexity and evolution in osteosarcoma, with prognostic implications for high-grade tumors.
bioRxiv · Dec 29, 2023 · PreprintCancer Biology