Author

T. C. Harding

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

K. K. Lin· 2 shared A. Barthelet· 1 shared A. Dobrovic· 1 shared A. E. Wahner Hendrickson· 1 shared A. Simmons· 1 shared A. Venkatachalam· 1 shared C. A. Ross· 1 shared C. Correia· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

K. K. Lin

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2 papers

Recent·Most cited

Characterization of a RAD51C-Silenced High Grade Serous Ovarian Cancer Model During PARP Inhibitor Resistance Development

R. M. Hurley, C. D. McGehee, K. Nesic, C. Correia, T. M. Weiskittel, R. L. Kelly, A. Venkatachalam, X. Hou, N. M. Pathoulas, X. W. Meng, O. Kondrashova, M. R. Radke, P. A. Schneider, K. S. Flatten, K. L. Peterson, , S. H. Kaufmann

This study shows that PARPi treatment can reverse RAD51C promoter methylation and restore expression in a high-grade serous ovarian cancer model, while maintaining platinum sensitivity.

bioRxiv · Dec 25, 2020Cancer Biology

A quantitative chemotherapy genetic interaction map reveals new factors associated with PARP inhibitor resistance

H.-M. Hu, X. Zhao, S. Kaushik, L. Robillard, A. Barthelet, K. K. Lin, A. Simmons, M. Raponi, T. C. Harding, S. Bandyopadhyay

This paper creates a quantitative chemical-genetic interaction map in human cells to identify factors affecting chemotherapy response and resistance.

bioRxiv · Aug 3, 2017Cancer Biology