S. Kaushik

Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy

This study shows Nrf1 promotes autophagy in response to proteotoxic stress, enhancing cell survival by upregulating autophagy pathway components.

Identification of merozoite secreted repertoire and immuno-pharmacological inhibition of a novel host-parasite interaction to block malarial infection

This study identifies the secretory repertoire of Plasmodium merozoites and discovers a peptide that disrupts a key host-parasite interaction, blocking malarial infection.

Effect of beneficial sweeps and background selection on genetic diversity in changing environments

The paper examines how periodic changes in selection coefficients affect genetic diversity through selective sweeps and background selection in populations.

Joint effect of changing selection and demography on the site frequency spectrum

The paper analyzes the site frequency spectrum under time-dependent selection and population size changes, showing deviations from equilibrium SFS in certain conditions.

Time to fixation in changing environments

The paper examines how fixation times of beneficial and deleterious mutants change in periodically varying environments, finding that beneficial mutations are less affected than recessive deleterious ones.

A Drug-free, Self-destruction Strategy to Combat Bacterial Infections by Using the Intrinsically formed Magnetic Nanoparticles in Bacterial Pathogens

This paper demonstrates a drug-free strategy using magnetic nanoparticles formed by bacteria to combat infections, showing significant bacterial reduction with an alternating magnetic field.

Targeting the artemisinin resistant malaria by repositioning of the anti-Hepatitis C Virus drug Alisporivir

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

A tyrosine kinase protein interaction map reveals targetable EGFR network oncogenesis in lung cancer

The paper constructs a tyrosine kinase protein interaction map, revealing EGFR network oncogenesis in 19% of EGFR wild-type lung cancers, which is targetable with EGFR inhibitors.

Development and Characterization of Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases

This study establishes and characterizes patient-derived xenografts of NSCLC brain metastases, showing strong phenotypic and molecular correlation with original tumors and therapeutic response to targeted treatments.

Oleocanthal and oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells

This study shows oleocanthal and oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells, reducing tumor burden and extending lifespan in mice.

A quantitative chemotherapy genetic interaction map reveals new factors associated with PARP inhibitor resistance

This paper creates a quantitative chemical-genetic interaction map in human cells to identify factors affecting chemotherapy response and resistance.