T. D. Y. Kozai

This study investigates how different microstimulation frequencies affect neural and hemodynamic responses in the mouse visual cortex, finding that lower frequencies enhance activation while higher frequencies induce depression.

This study shows that LIPUS reduces microglial activation and improves tissue-microelectrode integration after intracortical implantation.

This study evaluates how electrode sharpness and insertion speed affect tissue damage when implanting high-density neural arrays in mice and rats, finding that electro-sharpened arrays and faster insertion reduce cellular damage and BBB compromise.

This study examines how chronic microelectrode implantation affects functional connectivity in different cortical layers and the hippocampus over 16 weeks, finding layer-specific impairments and altered interlaminar communication.

This study investigates how long-term microelectrode implantation impairs autophagy-lysosomal activity, leading to tissue degeneration near the implant.

This study uses two-photon microscopy to observe astrocyte reactivity in mouse brains after intracortical microelectrode implantation, revealing distinct spatiotemporal dynamics compared to other glial cells.

This paper describes a method combining chronic calcium imaging and deep brain stimulation in a Parkinson's disease mouse model to study neuromodulation effects.

This study shows that asymmetric electrical stimulation waveforms modulate neuronal activation patterns in mice, with cathodic asymmetry reducing spatial spread and anodic asymmetry increasing it.