Author

T. E. Ouldridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3 Bioengineering· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:DNA methylation· 6 Approach:experimental assay· 5 Research Focus:synaptic & neural circuits· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

G.-B. V. Stan· 3 shared J. Cabello-Garcia· 3 shared W. Bae· 3 shared A. Sengar· 2 shared F. Smith· 2 shared J. Goertz· 2 shared R. Mukherjee· 2 shared F. Hong· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

G.-B. V. Stan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Kinetic Proofreading can Enhance Specificity in a Non-enzymatic DNA Strand Displacement Network

R. Mukherjee, A. Sengar, J. Cabello-Garcia, T. E. Ouldridge

This study introduces a DNA strand displacement-based kinetic proofreading motif that enhances molecular recognition specificity in templated dimerization reactions by consuming DNA-based fuel.

bioRxiv · Aug 25, 2023Biophysics

Information propagation through enzyme-free catalytic templating of DNA dimerization with weak product inhibition

J. Cabello-Garcia, R. Mukherjee, W. Bae, G.-B. V. Stan, T. E. Ouldridge

This study presents an enzyme-free DNA templating system that produces sequence-specific dimers with weak product inhibition, demonstrating a design principle for information propagation through molecular templating.

bioRxiv · Aug 23, 2023Bioengineering

Overcoming the speed limit of four-way DNA branch migration with bulges in toeholds

F. Smith, A. Sengar, G.-B. V. Stan, T. E. Ouldridge, M. Stevens, J. Goertz, W. Bae

This paper introduces a method to enhance four-way DNA exchange reaction kinetics by adding bulges to toeholds, making it faster and more efficient, closer to three-way reactions.

bioRxiv · May 15, 2023 · PreprintBiophysics

Mechanisms underlying sequence-dependent DNA hybridisation rates in the absence of secondary structure

S. Hertel, R. Spinney, S. Xu, T. E. Ouldridge, R. Morris, L. Lee

The paper measures DNA hybridisation rates of sequences without secondary structure and develops a model based on complementary nucleating interactions and sequence-dependent stability.

bioRxiv · Dec 17, 2021 · PreprintBiochemistry

Kinetics of RNA and RNA:DNA hybrid strand displacement

H. Liu, F. Hong, F. Smith, J. Goertz, T. E. Ouldridge, H. Yan, P. Sulc

This study experimentally examines how toehold length, location, and mismatches affect strand displacement kinetics in RNA and RNA-DNA hybrid systems.

bioRxiv · Apr 1, 2021 · PreprintBioengineering

Handhold-mediated strand displacement: a nucleic acid-based mechanism for generating far-from-equilibrium assemblies through templated reactions

J. Cabello-Garcia, W. Bae, G.-B. V. Stan, T. E. Ouldridge

This paper introduces handhold-mediated strand displacement (HMSD) as a method to enable templating in nucleic acid reactions, demonstrating its ability to accelerate and control DNA duplex assembly.

bioRxiv · May 22, 2020Biophysics