R. Morris

Generation of a biliary tract cancer cell line atlas reveals molecular subtypes and therapeutic targets

This study creates a biliary tract cancer cell line atlas using multi-omics data to identify molecular subtypes and therapeutic targets.

Adipose microenvironment promotes hypersialylation of ovarian cancer cells

This study shows that the adipose microenvironment increases sialylation in ovarian cancer cells, promoting tumor growth in immune-dependent settings.

Inter-modality source coupling: a fully- automated whole-brain data-driven structure- function fingerprint shows replicable links to reading in a large-scale (N~8K) analysis

This paper introduces IMSC, a method to analyze coupling between brain structure and function, and finds that reading ability correlates with specific patterns of function-structure coupling in children.

CDKN1B (p27kip1) enhances drug tolerant persister CTCs by restricting polyploidy following mitotic inhibitors.

This study identifies CDKN1B as a regulator of drug-tolerant persister CTCs by preventing polyploidy after mitotic inhibitor treatment in breast cancer.

Protein interactome homeostasis through an N-recognin E3 ligase is a vulnerability in aneuploid cancer

The paper identifies UBR4 as a critical mediator of protein interactome homeostasis in aneuploid cancers, showing its inactivation causes proteotoxic stress and convergence of copy number and protein levels.

Rare SH2B3 coding variants identified in lupus patients impair B cell tolerance and predispose to autoimmunity

The paper identifies rare SH2B3 variants in lupus patients that impair B cell tolerance and increase autoimmunity risk by affecting IL-4R signaling and BAFF-R expression.

Optimizing Short-format Training: an International Consensus on Effective, Inclusive, and Career-spanning Professional Development in the Life Sciences and Beyond

This paper presents 14 recommendations to improve short-format training in STEMM fields through a framework called the Bicycle Principles, aiming to make training more effective, inclusive, and career-spanning.

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

This study shows LKB1 suppresses JNK-dependent stress signaling in KRAS-mutant lung cancers, revealing a therapy-induced vulnerability that could improve KRAS-targeted therapies.

Considering decoupled phenotypic diversification between ontogenetic phases in macroevolution: An example using Triggerfishes (Balistidae)

The paper examines ontogenetic variation in locomotor morphology of triggerfishes, revealing decoupled diversification dynamics between adult and juvenile stages.

Mechanisms underlying sequence-dependent DNA hybridisation rates in the absence of secondary structure

The paper measures DNA hybridisation rates of sequences without secondary structure and develops a model based on complementary nucleating interactions and sequence-dependent stability.

Phylogenetic diversity of 200+ isolates of the ectomycorrhizal fungus Cenococcum geophilum associated with Populus trichocarpa soils in the Pacific Northwest, USA and comparison to globally distributed representatives

The paper analyzes phylogenetic diversity of Cenococcum geophilum isolates from Populus trichocarpa soils in the Pacific Northwest and globally distributed isolates, revealing cryptic species and recombination patterns.

Formation of functional, non-amyloidogenic fibres by recombinant Bacillus subtilis TasA

This paper shows recombinant Bacillus subtilis TasA forms functional, non-amyloidogenic fibres with properties similar to native fibres, revealing species-specific biofilm matrix assembly requirements.

Transcriptional variation and divergence of host-finding behaviour in Steinernema carpocapsae infective juveniles

This study identifies transcriptional differences and microRNA variation associated with host-finding behaviour variation in Steinernema carpocapsae strains.

Regulatory divergence of flowering time genes in the allopolyploid Brassica napus

This study examines how duplicated flowering time genes are regulated in Brassica napus, finding diverged expression patterns and cis-regulatory differences that impact gene retention.