Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores
C. F. Dickson, S. Hertel, J. Ruan, N. Ariotti, A. Tuckwell, N. Li, S. Al-Izzi, E. Sierecki, Y. Gambin, R. G. Morris, G. J. Towers, T. Boecking, D. A. Jacques
This paper shows how the HIV capsid mimics karyopherins to penetrate nuclear pores by interacting with FG-motifs, enabling it to bypass the size limit of the nuclear pore complex.
bioRxiv · Mar 23, 2023 · PreprintBiochemistry