Temporally integrated single cell RNA sequencing analysis of controlled and natural primary human DENV-1 infections
A. Waickman, H. Friberg, G. Gromowski, W. Rutvisuttinunt, T. Li, H. Siegfried, K. Victor, M. McCracken, S. Fernandez, A. Srikiatkhachorn, D. Ellison, R. G. Jarman, S. Thomas, A. L. Rothman, T. Endy, J. R. Currier
The paper compares the transcriptional responses of controlled and natural primary DENV-1 infections using scRNA-seq, finding similar inflammatory responses but more pronounced suppression of translation and mitochondrial function in natural infections.
bioRxiv · Jul 16, 2020Immunology