S. Fernandez

Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy

This study investigates how different routes of Listeria monocytogenes administration affect tumor growth in mice, finding that IV followed by IT administration controls tumor growth through anti-Lm CD8 T cells.

Extraordinary Evasion of Neutralizing Antibody Response by Omicron XBB.1.5, CH.1.1 and CA.3.1 Variants

This study evaluates neutralizing antibody escape by Omicron subvariants XBB.1.5, CH.1.1, and CA.3.1, showing near-complete escape from mRNA vaccines but partial rescue with bivalent boosters.

Distinct Neutralizing Antibody Escape of SARS-CoV-2 Omicron Subvariants BQ.1, BQ.1.1, BA.4.6, BF.7 and BA.2.75.2

This study evaluates neutralization resistance and immune evasion mechanisms of SARS-CoV-2 Omicron subvariants against various sera, identifying key mutations driving resistance.

Historical biogeography of Cannabis in the Iberian Peninsula: palynological evidence

This paper uses palynological evidence from nearly 60 Iberian Peninsula sites to analyze the historical spread of Cannabis sativa and its potential links to climate and human activity.

Bovine polyomavirus-1 (Epsilonpolyomavirus bovis): An emerging fetal pathogen of cattle that causes renal lesions resembling polyomavirus-associated nephropathy of humans

This paper describes pathological findings in a bovine fetus naturally infected with BoPyV-1, demonstrating its pathogenicity and potential to cause renal lesions similar to human polyomavirus-associated nephropathy.

Structural basis for tunable affinity and specificity of LxCxEdependentprotein interactions with the retinoblastoma protein family

This study presents crystal structures of the p107 pocket domain bound to LxCxE peptides, revealing structural determinants that explain differences in binding affinity between viral and cellular proteins.

Glioblastoma embryonic-like stem cells exhibit immune-evasive phenotype

The paper identifies a stem cell population in glioblastoma with embryonic signatures and poor immunogenicity, suggesting a mechanism for immune evasion.

SARS-CoV-2 RBD-Tetanus toxoid conjugate vaccine induces a strong neutralizing immunity in preclinical studies

Vector and cell-culture passaging of dengue clinical samples for virus isolation and amplification does not significantly change genome consensus or frequencies of intra-host viral variants

This study shows that low-passage dengue virus isolates preserve the consensus sequence and intra-host variant frequencies of their clinical samples, making them suitable for genomic epidemiology.

Temporally integrated single cell RNA sequencing analysis of controlled and natural primary human DENV-1 infections

The paper compares the transcriptional responses of controlled and natural primary DENV-1 infections using scRNA-seq, finding similar inflammatory responses but more pronounced suppression of translation and mitochondrial function in natural infections.

Analysis of cell-associated DENV RNA by oligo(dT) primed 5' capture scRNAseq

This study uses 5' capture scRNAseq to detect and quantify DENV RNA in infected cells, revealing viral sequence variability and identifying infected cell types.

Integrative analysis of transcriptomic and clinical data uncovers the tumor suppressive activity of MITF in prostate cancer.

The paper identifies MITF as a tumor suppressor in prostate cancer and reveals CRYAB as a direct target mediating its suppressive activity through integrative transcriptomic and clinical analysis.