J. R. Currier

Soluble NS1 antagonizes IgG- and IgA-mediated monocytic phagocytosis of DENV infected cells

This study shows soluble NS1 inhibits IgG- and IgA-mediated phagocytosis of DENV-infected cells by blocking opsonization.

A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model

This study evaluates a SARS-CoV-2 Spike ferritin nanoparticle vaccine in cynomolgus macaques, showing strong immunological responses and protection against infection.

Evolution of inflammation and immunity in a dengue virus 1 human infection model

This study analyzes the immune and virologic responses in humans infected with DENV-1, revealing new insights into the kinetics and composition of immune responses and gene modules involved in DENV infection.

mRNA-1273 vaccination protects against SARS-CoV-2 elicited lung inflammation in non-human primates

mRNA-1273 vaccination reduces lower respiratory tract inflammation in SARS-CoV-2 challenged rhesus macaques by limiting viral replication and inflammatory gene expression.

Monomeric IgA antagonizes IgG-mediated enhancement of DENV infection

This study shows that monomeric IgA can neutralize DENV and block IgG-mediated antibody-dependent enhancement (ADE) in vitro.

A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters

This study evaluates a SARS-CoV-2 spike ferritin nanoparticle vaccine's effectiveness against B.1.1.7 and B.1.351 variants in hamsters, showing protection against disease and viral replication.

A spike-ferritin nanoparticle vaccine induces robust innate immune activity and drives polyfunctional SARS-CoV-2-specific T cells

This study evaluates a spike-ferritin nanoparticle vaccine with adjuvants, showing enhanced T cell responses and cross-reactivity against SARS-CoV and other coronaviruses.

Efficacy and breadth of adjuvanted SARS-CoV-2 receptor-binding domain nanoparticle vaccine in macaques

This study evaluates an adjuvanted SARS-CoV-2 RBD nanoparticle vaccine in macaques, showing robust immune responses and protection against viral challenge and variants.

Efficacy of a Broadly Neutralizing SARS-CoV-2 Ferritin Nanoparticle Vaccine in Nonhuman Primates

A SARS-CoV-2 Spike ferritin nanoparticle vaccine induces broad neutralizing antibodies and protects nonhuman primates against respiratory infection and disease.

Temporally integrated single cell RNA sequencing analysis of controlled and natural primary human DENV-1 infections

The paper compares the transcriptional responses of controlled and natural primary DENV-1 infections using scRNA-seq, finding similar inflammatory responses but more pronounced suppression of translation and mitochondrial function in natural infections.

Analysis of cell-associated DENV RNA by oligo(dT) primed 5' capture scRNAseq

This study uses 5' capture scRNAseq to detect and quantify DENV RNA in infected cells, revealing viral sequence variability and identifying infected cell types.

Dissecting the heterogeneity of DENV vaccine-elicited cellular immunity using single-cell RNA sequencing and cellular metabolic profiling

This study uses single-cell RNA sequencing and metabolic profiling to identify metabolic signatures of durable T cell memory in DENV vaccine responses.