ImmunologybioRxiv
Antibody escape and cryptic cross-domain stabilization in the SARS CoV-2 Omicron spike protein
K. Javanmardi, T. H. Segall-Shapiro, C.-W. Chou…·J. D. Gollihar
This study examines the molecular effects of Omicron spike mutations on ACE2 binding and antibody escape, revealing compensatory stabilizing mutations that enable high mutation counts.
DOI 10.1016/j.chom.2022.07.016