The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells
T. Hodgkinson, M. Tsimbouri, V. Llopis-Hernandez, P. Campsie, D. Scurr, P. Childs, D. Phillips, S. Donnelly, J. Wells, M. Salmeron-Sanchez, K. Burgess, M. R. Alexander, M. Vassalli, R. Oreffo, S. R. Reid, , M. J. Dalby
This study uses nanovibration to induce osteogenic differentiation in MSCs without exogenous growth factors, identifying cholesterol sulphate and fludrocortisone acetate as potent bioactive metabolites.
bioRxiv · Feb 7, 2020Bioengineering