M. J. Dalby

Developing and Investigating a Nanovibration Intervention for the Prevention/Reversal of Bone Loss Following Spinal Cord Injury

This study tests a nanovibration device for reversing bone loss after spinal cord injury in rats, finding no reversal but increased collagen synthesis markers.

Gut microbiota and faecal cytokine profiles of rural Cambodian infants and links to early life nutrition and diarrhoeal episodes.

This study examines gut microbiota and cytokine profiles in rural Cambodian infants, finding associations between breastfeeding, pathogen exposure, and microbial composition.

Extracellular vesicle cargo metabolome changes in response to the mesenchymal stromal cell microenvironment and influences cell quiescence and activation in a human breast cancer cell model

This study shows that MSC-derived extracellular vesicles carry metabolites that maintain breast cancer cell dormancy, and their absence promotes activation under regenerative conditions.

Bioengineered niches that recreate physiological extracellular matrix organisation to support long-term haematopoietic stem cells

This study develops a bioengineered niche that maintains long-term haematopoietic stem cells by recreating physiological extracellular matrix organisation, supporting their survival and function without media supplementation.

Maternal microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice

This study shows that Bifidobacterium breve UCC2003 in the maternal gut microbiota promotes placental development, nutrient transport, and fetal growth in mice.

Bifidobacterium breve UCC2003 exopolysaccharide modulates the early life microbiota by acting as a dietary substrate

This study shows that Bifidobacterium breve UCC2003 exopolysaccharide (EPS) alters infant microbiota and metabolite profiles by serving as a nutrient substrate.

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

This study uses nanovibration to induce osteogenic differentiation in MSCs without exogenous growth factors, identifying cholesterol sulphate and fludrocortisone acetate as potent bioactive metabolites.

Engineered full-length Fibronectin-based hydrogels sequester and present growth factors to promote regenerative responses in vitro and in vivo

This study develops fibronectin-based hydrogels that present growth factors to enhance angiogenesis and bone regeneration in vitro and in vivo.

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding

This study shows that early life gut microbiota in mice prevents pathological small intestinal epithelial cell shedding, with antibiotic treatment reversing this protection.

Design, construction and characterisation of a novel nanovibrational bioreactor and cultureware for osteogenesis

The paper designs and validates a nanovibrational bioreactor system to stimulate osteogenesis in mesenchymal stem cells through mechanical stimulation without chemical induction.