M. R. Alexander

Spatially resolved molecular analysis of host response to medical device implantation using the 3D OrbiSIMS

The paper uses 3D OrbiSIMS to analyze metabolite signatures in tissue around implanted medical devices, linking them to pro- or anti-inflammatory immune responses.

Polymer-directed inhibition of reversible to irreversible attachment prevents Pseudomonas aeruginosa biofilm formation

This study identifies how specific acrylate polymers inhibit Pseudomonas aeruginosa biofilm formation by preventing the transition from reversible to irreversible attachment.

Ribosome-profiling reveals restricted post transcriptional ex-pression of antiviral cytokines and transcription factors during SARS-CoV-2 infection

This study uses ribosome profiling to show that SARS-CoV-2 restricts post-transcriptional expression of antiviral cytokines and transcription factors in human lung cells.

In situ protein identification and mapping using secondary ion mass spectrometry

This paper demonstrates the use of secondary ion mass spectrometry to directly identify and map proteins at surfaces without prior digestion.

AbaM Regulates Quorum Sensing, Biofilm Formation and Virulence in Acinetobacter baumannii

This paper identifies abaM as a regulator of quorum sensing, biofilm formation, and virulence in Acinetobacter baumannii, showing that its disruption attenuates virulence while increasing AHL production and biofilm formation.

Micro topographical instruction of bacterial attachment, biofilm formation and in vivo host response

The paper identifies micro topographies that reduce bacterial attachment and biofilm formation, and show promise in preventing medical device infections in a mouse model.

Sequential 3D OrbiSIMS and LESA-MS/MS-based metabolomics for prediction of brain tumor relapse from sample-limited primary tissue archives

The paper uses sequential 3D OrbiSIMS and LESA-MS/MS to profile metabolites in FFPE pediatric ependymoma tissues and predict tumor relapse.

Inkjet based 3D Printing of bespoke medical devices that resist bacterial biofilm formation

This paper develops 3D printing inks that resist bacterial biofilm formation and demonstrate their use in a finger prosthetic to prevent infection.

Synergistic Material-Topography Combinations to Achieve Immunomodulatory Osteogenic Biomaterials

The paper identifies synergistic material-topography combinations that direct hMSC fate and modulate macrophage phenotype for bone regeneration.

Designing Topographically Textured Microparticles For Induction and Modulation of Osteogenesis in Mesenchymal Stem Cell Engineering

This study shows that topographically textured microparticles can enhance osteogenic markers in mesenchymal stem cells without exogenous factors.

The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells

This study uses nanovibration to induce osteogenic differentiation in MSCs without exogenous growth factors, identifying cholesterol sulphate and fludrocortisone acetate as potent bioactive metabolites.

Cryo-OrbiSIMS for 3D molecular imaging of a bacterial biofilm in its native state

This paper introduces Cryo-OrbiSIMS for 3D molecular imaging of bacterial biofilms, revealing the spatial distribution of quorum sensing molecules and membrane components in Pseudomonas aeruginosa.

Simultaneous tracking of Pseudomonas aeruginosa motility in liquid and at the solid-liquid interface reveals differential roles for the flagellar stators

The paper develops a method to track Pseudomonas aeruginosa motility in liquid and at solid-liquid interfaces, revealing differential roles of flagellar stators motAB and motCD.