Author

T. J. Gardella

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:protein structure· 1

Frequent Co-Authors

B. A. Creemer· 1 shared B. P. Cary· 1 shared K. Nguyen· 1 shared R. Cheloha· 1 shared S. H. Gellman· 1 shared S. Sachdev· 1 shared T. W. Kim· 1 shared Z. Yu· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 13 mutual co-author links

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1 shared paperPharmacology & Toxicology

B. A. Creemer

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2 papers

Recent·Most cited

Highly biased agonism for GPCR ligands via nanobody tethering

S. Sachdev, B. A. Creemer, T. J. Gardella, R. Cheloha

The paper describes a method to create highly biased agonists for GPCRs by tethering a peptide ligand to a nanobody, achieving pathway selectivity without altering the core ligand structure.

bioRxiv · Oct 10, 2023 · PreprintPharmacology & Toxicology

Kinetic and Thermodynamic Insights on Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET assay

Z. Yu, B. P. Cary, T. W. Kim, K. Nguyen, T. J. Gardella, S. H. Gellman

The paper introduces a new NanoBRET assay to study agonist interactions with PTHR1, revealing kinetic and thermodynamic insights into ligand binding and activation.

bioRxiv · Jul 25, 2022Biochemistry