Author

B. P. Cary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

D. Wootten· 2 shared M. J. Belousoff· 2 shared P. M. Sexton· 2 shared S. H. Gellman· 2 shared S. J. Piper· 2 shared E. J. Gerrard· 1 shared I. C. Russell· 1 shared K. Nguyen· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

D. Wootten

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Author profile →

3 papers

Recent·Most cited

Molecular insights into peptide agonist engagement with the PTH1 receptor

B. P. Cary, E. J. Gerrard, M. J. Belousoff, M. M. Fletcher, Y. Jiang, I. C. Russell, S. J. Piper, D. Wootten, P. M. Sexton

This study presents cryo-EM structures of the PTH1R bound to various agonists, revealing how different peptides engage the receptor and providing insights for drug design.

bioRxiv · Sep 4, 2022 · PreprintBiochemistry

Kinetic and Thermodynamic Insights on Agonist Interactions with the Parathyroid Hormone Receptor-1 from a New NanoBRET assay

Z. Yu, B. P. Cary, T. W. Kim, K. Nguyen, T. J. Gardella, S. H. Gellman

The paper introduces a new NanoBRET assay to study agonist interactions with PTHR1, revealing kinetic and thermodynamic insights into ligand binding and activation.

bioRxiv · Jul 25, 2022Biochemistry

Structural and Functional Diversity among Agonist-Bound States of the GLP-1 Receptor

B. P. Cary, P. Zhao, T. T. Truong, S. J. Piper, M. J. Belousoff, R. Danev, P. M. Sexton, D. Wootten, S. H. Gellman

This study investigates how peptide agonist conformational plasticity influences GLP-1R activation through structural and functional analysis.

bioRxiv · Feb 24, 2021Pharmacology & Toxicology