Structurally related but genetically unrelated antibody lineages converge on an immunodominantHIV-1 Env neutralizing determinant following trimer immunization
S. Aljedani, T. J. Liban, K. Tran, G. Phad, S. Singh, V. Dubrovskaya, P. Pushparaj, P. Martinez-Murillo, J. Rodarte, A. Mileant, V. Mangala, R. Kinzelman, S. O'Dell, J. R. Mascola, K. K. Lee, , M. Pancera
The paper analyzes monoclonal antibodies from vaccinated non-human primates to identify a conserved immunodominant epitope in HIV-1 Env and how different lineages target it for potent neutralization.
bioRxiv · Apr 9, 2021Biochemistry