Author

T. J. Parnell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

G. Fort· 2 shared A. Jones· 1 shared B. Lohman· 1 shared B. T. Spike· 1 shared C. Stubben· 1 shared C. Vakoc· 1 shared E. L. Snyder· 1 shared E. Snyder· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

G. Fort

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2 papers

Recent·Most cited

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma

K. Gillis, W. A. Orellana, E. Wilson, T. J. Parnell, G. Fort, H. E. Dadzie, X. Zhang, E. Snyder

This study shows FoxA1/2 reprogram the epigenome of NKX2-1-negative lung adenocarcinoma to drive a gastric lineage switch through DNA demethylation and regulatory element activation.

bioRxiv · Oct 30, 2023Cancer Biology

FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma

G. Orstad, G. Fort, T. J. Parnell, A. Jones, C. Stubben, B. Lohman, K. L. Gillis, W. Orellana, R. Tariq, O. Klingbeil, K. H. Kaestner, C. Vakoc, B. T. Spike, E. L. Snyder

This study shows that FoxA1/2 are critical for tumorigenesis and cellular identity in NKX2-1-positive lung adenocarcinoma, with their loss impairing tumor growth and altering transcriptional programs.

bioRxiv · Jun 29, 2021 · PreprintCancer Biology