Author

B. T. Spike

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:differential expression· 2

Frequent Co-Authors

E. M. Mehrabad· 3 shared A. Jones· 2 shared B. L. Gates· 2 shared D. W. Freeman· 2 shared E. L. Snyder· 2 shared G. Orstad· 2 shared K. L. Gillis· 2 shared A. Butterfield· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCancer Biology

E. M. Mehrabad

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CRIPTO promotes extracellular vesicle uptake and activation of fibroblasts exposed to triple negative breast cancer cells

D. W. Freeman, B. L. Gates, M. D. Spendlove, H. E. Gulbahce, B. T. Spike

This study identifies CRIPTO's role in promoting extracellular vesicle uptake and fibroblast activation in TNBC, revealing a mechanism for tumor-stromal communication and potential therapeutic targets.

bioRxiv · Mar 1, 2024 · PreprintCancer Biology

OCA-B promotes pathogenic maturation 1 of stem-like CD4+ T cells and autoimmune demyelination

E. P. Hughes, A. R. Syage, E. M. Mehrabad, T. E. Lane, B. T. Spike, D. Tantin

This study identifies OCA-B as a driver of pathogenic maturation in stem-like CD4+ T cells, promoting autoimmune demyelination in multiple sclerosis.

bioRxiv · Nov 29, 2023Immunology

Mcam stabilizes luminal progenitor breast cancer phenotypes via Ck2 control and Src/Akt/Stat3 attenuation

O. Balcioglu, B. L. Gates, D. W. Freeman, B. M. Hagos, E. M. Mehrabad, D. Ayala-Talavera, B. T. Spike

This study shows Mcam stabilizes luminal progenitor breast cancer phenotypes by regulating Ck2 and attenuating Stat3, Src/Akt/Stat3 signaling, and cell state transitions.

bioRxiv · May 10, 2023 · PreprintCancer Biology

Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer

E. R. Polanco, T. E. Moustafa, A. Butterfield, S. D. Scherer, E. Cortes-Sanchez, T. Bodily, B. T. Spike, B. E. Welm, P. S. Bernard, T. A. Zangle

This study uses multiparametric quantitative phase imaging to assess drug response in breast cancer cells, revealing single-cell heterogeneity and resistance dynamics.

bioRxiv · Nov 26, 2021Bioengineering

FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma

G. Orstad, G. Fort, T. J. Parnell, A. Jones, C. Stubben, B. Lohman, K. L. Gillis, W. Orellana, R. Tariq, O. Klingbeil, K. H. Kaestner, C. Vakoc, B. T. Spike, E. L. Snyder

This study shows that FoxA1/2 are critical for tumorigenesis and cellular identity in NKX2-1-positive lung adenocarcinoma, with their loss impairing tumor growth and altering transcriptional programs.

bioRxiv · Jun 29, 2021 · PreprintCancer Biology

An NKX2-1/ERK/WNT feedback loop modulates gastric identity and response to targeted therapy in lung adenocarcinoma

R. Zewdu, E. M. Mehrabad, K. Ingram, P. Fang, K. L. Gillis, S. A. Camolotto, G. Orstad, A. Jones, M. C. Mendoza, B. T. Spike, E. L. Snyder

bioRxiv · Feb 25, 2020Cancer Biology