Author

K. H. Kaestner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

G. Vahedi· 2 shared M. Brissova· 2 shared A. C. Powers· 1 shared A. Jones· 1 shared A. M. Zahm· 1 shared A. Morgan· 1 shared A. Naji· 1 shared A. Powers· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersPhysiology

G. Vahedi

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Alpha cell dysfunction in early type 1 diabetes

N. Doliba, A. Rozo, J. Roman, W. Qin, D. Traum, L. Gao, J. Liu, E. Manduchi, C. Liu, M. Golson, G. Vahedi, A. Naji, F. Matschinsky, M. Atkinson, A. Powers, , D. Stoffers

The paper identifies early alpha cell dysfunction in individuals with GADA+ status, preceding beta cell loss in T1D, and links it to metabolic pathway abnormalities.

bioRxiv · Oct 15, 2021 · PreprintPhysiology

FoxA1 and FoxA2 regulate growth and cellular identity in NKX2-1-positive lung adenocarcinoma

G. Orstad, G. Fort, T. J. Parnell, A. Jones, C. Stubben, B. Lohman, K. L. Gillis, W. Orellana, R. Tariq, O. Klingbeil, K. H. Kaestner, C. Vakoc, B. T. Spike, E. L. Snyder

This study shows that FoxA1/2 are critical for tumorigenesis and cellular identity in NKX2-1-positive lung adenocarcinoma, with their loss impairing tumor growth and altering transcriptional programs.

bioRxiv · Jun 29, 2021 · PreprintCancer Biology

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

K. C. Coate, J. Cha, S. Shrestha, W. Wang, L. M. Goncalves, J. Almaca, M. E. Kapp, M. Fasolino, A. Morgan, C. Dai, D. C. Saunders, R. Bottino, R. Aramandla, R. Jenkins, R. Stein, , A. C. Powers

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

bioRxiv · Aug 31, 2020 · PreprintCell Biology

In vivo screen identifies LXR agonism potentiates sorafenib killing of hepatocellular carcinoma

M. E. Preziosi, A. M. Zahm, A. Vasquez-Salgado, D. Ackerman, T. Gade, K. H. Kaestner, K. J. Wangensteen

The paper identifies LXR agonism as a potential enhancer of sorafenib's efficacy in treating hepatocellular carcinoma through an in vivo genetic screen and mechanistic studies.

bioRxiv · Jun 13, 2019 · PreprintCancer Biology