Author

T. J. Sargeant

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Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

C. G. Proud· 1 shared J. Bruning· 1 shared J. Xie· 1 shared L. K. Hein· 1 shared S. J. Humphrey· 1 shared S. P. De Poi· 1 shared W. Pan· 1 shared

Activity by Year

2020-2020 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

C. G. Proud

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1 paper

Recent·Most cited

TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming

C. G. Proud, S. P. De Poi, J. Xie, S. J. Humphrey, L. K. Hein, J. Bruning, W. Pan, T. J. Sargeant

This study identifies two Rheb mutants that drive oncogenic transformation via hyperactive mTORC1 signaling and distinct metabolic reprogramming pathways.

bioRxiv · Sep 5, 2020Cell Biology