Author

S. J. Humphrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

C. Mackenzie-Kludas· 2 shared D. A. Elliott· 2 shared D. Abu-Bonsrah· 2 shared K. Karavendzas· 2 shared K. Subbarao· 2 shared A. Salavaty· 1 shared A. Suhrbier· 1 shared B. Griffen· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

C. Mackenzie-Kludas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2

R. Rudraraju, M. J. Gartner, J. A. Neil, E. S. Stout, J. Chen, E. J. Needham, M. See, C. Mackenzie-Kludas, L. Y. Yang, M. Wang, H. Pointer, K. Karavendzas, D. Abu-Bonsrah, D. Drew, Y. B. Y. Sun, , K. Subbarao

The paper uses human pluripotent stem cell-derived lung and heart models to identify antiviral compounds with distinct profiles, highlighting the need for multi-organ testing in SARS-CoV-2 treatment.

bioRxiv · Sep 20, 2022 · PreprintMicrobiology

Environmental control of Pub1 (NEDD4 family E3 ligase) in S. pombe is regulated byTORC2 and Gsk3.

T. Wang, P. Woodman, S. J. Humphrey, J. Petersen

The paper shows that TORC2 and Gsk3 regulate Pub1 in S. pombe, affecting amino acid transporter abundance and canavanine sensitivity under nitrogen stress.

bioRxiv · Feb 21, 2021 · PreprintCell Biology

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

X. Duan, D. M. Norris, S. J. Humphrey, P. Yang, K. C. Cooke, W. P. Bultitude, B. L. Parker, O. J. Conway, J. G. Burchfield, J. R. Krycer, F. M. Brodsky, D. E. James, D. J. Fazakerley

This study identifies TRARG1 as a GSK3 substrate that regulates GLUT4 trafficking and insulin sensitivity through phosphorylation events.

bioRxiv · Dec 7, 2020Cell Biology

TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming

C. G. Proud, S. P. De Poi, J. Xie, S. J. Humphrey, L. K. Hein, J. Bruning, W. Pan, T. J. Sargeant

This study identifies two Rheb mutants that drive oncogenic transformation via hyperactive mTORC1 signaling and distinct metabolic reprogramming pathways.

bioRxiv · Sep 5, 2020Cell Biology

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

R. J. Mills, S. J. Humphrey, P. R. Fortuna, M. Lor, S. R. Foster, G. A. Quaife-Ryan, R. L. Johnston, T. Dumenil, C. Bishop, R. Ruraraju, D. J. Rawle, T. Le, W. Zhao, L. Lee, C. Mackenzie-Kludas, , E

The paper identifies BET inhibitors as potential cardio-protective drugs that block inflammation-induced cardiac dysfunction and SARS-CoV-2 infection in pre-clinical models.

bioRxiv · Aug 23, 2020 · PreprintCell Biology