Author

C. G. Proud

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

J. Xie· 2 shared X. Jin· 2 shared A. Okamoto· 1 shared B. K. Dredge· 1 shared C. Zorbas· 1 shared D. L. Lafontaine· 1 shared D. M. W. Fang· 1 shared G. J. Goodall· 1 shared

Activity by Year

2020-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

J. Xie

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Author profile →

5 papers

Recent·Most cited

Glutamine deficiency in solid tumors confers resistance to ribosomal RNA synthesis inhibitors

M. Pan, C. Zorbas, M. Sugaya, K. Ishiguro, M. Kato, M. Nishida, H. Zhang, M. M. Candeias, A. Okamoto, T. Ishikawa, T. Soga, H. Aburatani, J. Sakai, Y. Matsumura, T. Suzuki, , T. Osawa

The paper shows that glutamine deficiency in cancer cells prevents p53 activation by rRNA synthesis inhibitors, promoting survival during nutrient stress.

bioRxiv · Dec 3, 2021 · PreprintCancer Biology

TSC-Insensitive Rheb Mutations Induce Oncogenic Transformation Through a Combination of Hyperactive mTORC1 Signalling and Metabolic Reprogramming

C. G. Proud, S. P. De Poi, J. Xie, S. J. Humphrey, L. K. Hein, J. Bruning, W. Pan, T. J. Sargeant

This study identifies two Rheb mutants that drive oncogenic transformation via hyperactive mTORC1 signaling and distinct metabolic reprogramming pathways.

bioRxiv · Sep 5, 2020Cell Biology

eEF2 kinase enhances the expression of PD-L1 by promoting the translation of its mRNA

C. G. Proud, Y. Wu, J. Xie, X. Jin, R. V. Lenchine, X. Wang, D. M. W. Fang, Z. NASSAR, L. M. Butler, J. Li

This study shows that eEF2K enhances PD-L1 expression by promoting its mRNA translation through a uORF in the 5-UTR, making cancer cells more vulnerable to immune attack.

bioRxiv · Sep 1, 2020Biochemistry

Identification of DNA response elements regulating expression of CCAAT/enhancer-binding protein (C/EBP) β and δ during early adipogenesis

J. E. Merrett, T. Bo, P. J. Psaltis, C. G. Proud

The paper identifies DNA response elements regulating C/EBPβ and C/EBPδ expression during early adipogenesis in 3T3-L1 cells and shows Mknk2 is induced and regulated by similar elements.

bioRxiv · May 22, 2020Biochemistry

capCLIP: a new tool to probe protein synthesis in human cells through capture and identification of the eIF4E-mRNA interactome.

K. B. Jensen, B. K. Dredge, J. Toubia, X. Jin, V. Iadevaia, G. J. Goodall, C. G. Proud

capCLIP captures and quantifies the eIF4E-mRNA interactome to measure translational activity, showing reduced TOP mRNA and altered eIF4E phosphorylation effects.

bioRxiv · Apr 18, 2020Biochemistry