Author

T. K. Sigdel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:batch correction / integration· 1 Research Focus:clustering· 1 Assay:multiome· 1

Frequent Co-Authors

M. M. Sarwal· 2 shared A. A. da Silva· 1 shared A. L. Lourenco· 1 shared A. Schroeder· 1 shared B. B. Lake· 1 shared B. Rovin· 1 shared B. Steck· 1 shared C. E. Alpers· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

M. M. Sarwal

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.

P. Rashmi, T. K. Sigdel, D. Rychkov, I. Damm, A. A. da Silva, F. Vincenti, A. L. Lourenco, C. S. Craik, J. Reiser, M. M. Sarwal

This paper investigates how circulating factors like suPAR and CD40 autoantibodies induce podocyte injury in FSGS and identifies therapeutic targets for rFSGS.

Annals of Translational Medicine · Jun 1, 2023Peer-reviewedImmunology

Novel Mechanism for Tubular Injury in Nephropathic Cystinosis

S. Sur, M. Kerwin, S. Pineda, P. Sansanwal, T. K. Sigdel, M. Sirota, M. M. Sarwal

This study identifies ATP6V0A1 downregulation in cystinosis as a key factor in tubular injury, showing that antioxidants like astaxanthin can restore mitochondrial function and autophagosome turnover.

bioRxiv · May 13, 2022Cell Biology

A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: The Kidney Precision Medicine Project

T. M. El-Achkar, M. T. Eadon, R. Menon, B. B. Lake, T. K. Sigdel, T. Alexandrov, S. Parikh, G. Zhang, D. Dobi, K. W. Dunn, E. A. Otto, C. R. Anderton, J. M. Carson, J. Luo, C. Park, , For the Kidney Precision Medicine Project

The paper describes a pipeline for generating 3D molecular atlases of human kidney biopsies using multi-OMICS and imaging technologies, emphasizing quality control and reproducibility across institutions.

bioRxiv · Aug 23, 2020 · PreprintScientific Communication & Education