Movements of ancient human endogenous retroviruses detected in SOX2-expressing cells
K. Monde, Y. Satou, M. Goto, Y. Uchiyama, J. Ito, T. Kaitsuka, H. Terasawa, S. Yamaga, T. Matsusako, F. Y. Wei, I. Inoue, K. Tomizawa, A. Ono, T. Era, T. Sawa, Y. Maeda
The paper shows SOX2 regulates HERV-K transcription and retrotransposition in stem cells, suggesting a role in embryonic protection while limiting genomic harm.
bioRxiv · Jul 14, 2020Microbiology