Author

I. Inoue

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Evolutionary Biology· 2 Biochemistry· 1 Cancer Biology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 6 Research Focus:chromatin & epigenetic regulation· 4 Assay:DNA methylation· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3

Frequent Co-Authors

Y. Takenaka· 6 shared Y. Kakinuma· 5 shared M. Ikeda· 4 shared M. Hirasaki· 3 shared T. Nakano· 3 shared H. Nakaoka· 2 shared J. Ito· 2 shared A. Coudray· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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6 shared papersCell Biology

Y. Takenaka

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Transcriptome analyses of mouse cardiac myocytes and non-cardiomyocytes: postmitotic vs. proliferative cells

Y. Takenaka, M. Hirasaki, I. Inoue, M. Ikeda, H. Ohata, Y. Kakinuma

This study compares gene expression in postmitotic cardiac myocytes and proliferative non-cardiomyocytes from young and aged mice, identifying age-related changes in mitochondrial genes and snoRNAs.

bioRxiv · Aug 20, 2023 · PreprintPhysiology

Positive feedback regulation of Pparγ1sv and Pparγ2 during adipogenesis in 3T3-L1 cells

Y. Takenaka, Y. Kakinuma, I. Inoue

The paper identifies PPARγ-binding sites in the Pparγ gene locus and proposes positive feedback regulation of Pparγ1sv and Pparγ2 during adipogenesis in 3T3-L1 cells.

bioRxiv · Aug 3, 2023 · PreprintCell Biology

Joint effects of balancing selection and population bottlenecks on the evolution of a regulatory region of human anti-viral APOBEC3

N. T. Fujito, R. Sundaramoorthy, Y. Satta, I. Inoue

The paper investigates how balancing selection and population bottlenecks shape genetic diversity in a human APOBEC3 regulatory region, identifying haplogroups and evolutionary mechanisms.

bioRxiv · Jul 18, 2023Evolutionary Biology

Temporal inhibition of electron transport chain attenuates stress-induced cellular senescence by prolonged disturbance of proteostasis in human fibroblasts

Y. Takenaka, I. Inoue, M. Hirasaki, M. Ikeda, Y. Kakinuma

The paper shows that inhibiting mitochondrial respiration with antimycin A reduces stress-induced senescence in human fibroblasts by improving proteostasis.

bioRxiv · Nov 7, 2022Cell Biology

Movements of ancient human endogenous retroviruses detected in SOX2-expressing cells

K. Monde, Y. Satou, M. Goto, Y. Uchiyama, J. Ito, T. Kaitsuka, H. Terasawa, S. Yamaga, T. Matsusako, F. Y. Wei, I. Inoue, K. Tomizawa, A. Ono, T. Era, T. Sawa, Y. Maeda

The paper shows SOX2 regulates HERV-K transcription and retrotransposition in stem cells, suggesting a role in embryonic protection while limiting genomic harm.

bioRxiv · Jul 14, 2020Microbiology

NPC1L1 inhibition disturbs lipid trafficking and induces large lipid droplet formation in intestinal absorptive epithelial cells

T. Nakano, I. Inoue, Y. Takenaka, R. Ito, N. Kotani, S. Sato, Y. Nakano, M. Hirasaki, A. Shimada, T. Murakoshi

This study shows that NPC1L1 inhibition reduces chylomicron assembly and secretion in intestinal cells by limiting cholesterol availability, leading to large lipid droplet formation.

bioRxiv · Apr 17, 2020Biochemistry

Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppression

J. Ito, I. Kimura, A. Soper, A. Coudray, Y. Koyanagi, H. Nakaoka, I. Inoue, P. Turelli, D. Trono, K. Sato

The paper shows HERV activation in tumors upregulates KZFPs, which suppress cancer progression by downregulating cell cycle and adhesion genes, improving disease outcomes.

bioRxiv · Feb 2, 2020Cancer Biology

Prolonged disturbance of proteostasis induces cellular senescence via temporal mitochondrial dysfunction and enhanced mitochondrial biogenesis in human fibroblasts

Y. Takenaka, I. Inoue, T. Nakano, M. Ikeda, Y. Kakinuma

This study shows that proteostasis disruption in human fibroblasts leads to mitochondrial dysfunction and biogenesis, contributing to cellular senescence through ROS accumulation and impaired antioxidant defenses.

bioRxiv · Jan 22, 2020 · PreprintCell Biology

Exome sequences of toque macaques (Macaca sinica) of Sri Lanka reveal many amino acid changes

N. N. Hettiarachchi, N. Osada, T. Hayakawa, H. Nakaoka, N. Saitou, I. Inoue

This study sequences the exome of toque macaques (M. sinica) from Sri Lanka, revealing genetic differences and phylogenetic relationships with other macaque species.

bioRxiv · Sep 4, 2019 · PreprintEvolutionary Biology

Epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells

Y. Takenaka, T. Nakano, M. Ikeda, Y. Kakinuma, I. Inoue

The paper investigates the epigenetic regulation of a mouse PPARγ splicing variant, Pparγ1sv, during adipogenesis in 3T3-L1 cells, finding changes in histone modifications but not DNA methylation.

bioRxiv · Jun 4, 2019 · PreprintCell Biology