Y. Maeda

Patho-transcriptomic analysis of invasive mucinous adenocarcinoma of the lung (IMA): comparison with lung adenocarcinoma with signet ring cell features (SRCC)

This study compares the patho-transcriptomic profiles of invasive mucinous adenocarcinoma (IMA) and adenocarcinoma with signet ring cell features (SRCC), identifying distinct and shared gene expression patterns and potential therapeutic targets.

A heterocyclic compound inhibits viral release by inducing cell surface BST2/Tetherin/CD317/HM1.24

This paper identifies a heterocyclic compound, HT-7, that inhibits HIV-1 release by increasing cell surface BST2 expression with minimal cellular toxicity.

SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses

This study shows that SARS-CoV-2 ORF8 protein acts as a cytokine that promotes lung inflammation and immune dysregulation in COVID-19, suggesting it as a potential therapeutic target.

Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction

This study develops a PCR-based reverse genetics system for SARS-CoV-2 using CPER to generate infectious clones with high accuracy and titer.

Movements of ancient human endogenous retroviruses detected in SOX2-expressing cells

The paper shows SOX2 regulates HERV-K transcription and retrotransposition in stem cells, suggesting a role in embryonic protection while limiting genomic harm.

Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation

The paper identifies B3GALT4's dual role in GPI and glycosphingolipid biosynthesis and shows ER-associated degradation suppresses GPI biosynthesis when GPI transfer to proteins is defective.