T. Kendall

TLR5 drives metabolic dysfunction-associated steatohepatitis through lipid- and flagellin-induced hepatocyte injury signalling

The paper investigates TLR5's role in MASH and fibrosis using clinical data, single-cell transcriptomics, and in vitro models, finding TLR5 drives hepatocyte injury and fibrosis through flagellin and lipid pathways.

Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

Mating system is associated with seed phenotypes upon loss of RNA-directed DNA Methylation in Brassicaceae

The paper investigates how the mating system affects seed production defects in RdDM mutants across Brassicaceae species, finding that outcrossing species show similar defects while selfing species do not.

Charophytic Green Algae encode ancestral Pol IV/Pol V subunits and a CLSY/DRD1 homolog

The paper identifies ancestral Pol IV/Pol V subunits and a CLSY/DRD1 homolog in Charophytic green algae, suggesting a single Pol V-like polymerase in early RdDM.

A novel CLAVATA1 mutation causes multilocularity in Brassica rapa

This study identifies a CLAVATA1 mutation in Brassica rapa that increases locule number and disrupts floral meristem termination.

A Null Allele of the Pol IV Second Subunit is Viable in Oryza sativa

This study identifies a null allele of NRPD2 in Oryza sativa, showing it is essential for small RNA production and CHH methylation in leaves, but not for gametophytic function or embryo viability.

Embryo CHH hypermethylation is mediated by RdDM and is autonomously directed in Brassica rapa

This study shows that embryo CHH hypermethylation in Brassica rapa is autonomously controlled by RdDM and not influenced by maternal sporophyte factors.

Abundant expression of maternal siRNAs is a conserved feature of seed development

The paper shows that maternal siRNAs are abundant and conserved in seed development across angiosperms, with a maternal bias in endosperm and dependence on RNA Pol IV/RDR2.

Maternal RNA-directed DNA methylation is required for seed development in Brassica rapa

This study shows that maternal small RNA pathway mutations cause seed abortion in Brassica rapa, revealing a role for maternal somatic tissues in seed development through RNA-directed DNA methylation.